Background: A neonate undergoes major physiologic changes during transition from intrauterine to extra-uterine period. In most of the babies this transition is smooth; however, 5- 10% needs some assistance in breathing, while 1% requires extensive resuscitation. Objectives: 1. To determine the length of time required to reach 90% or more in preductal saturation 2. To corelate maximum oxygen saturation to the Mode of delivery, Gestational Age, Gender and Weight. Methods: All healthy singleton full-term neonates delivered vaginally (n=50) and by caesarean section (n=50) who fall under inclusion and exclusion criteria are selected for the study. Neonates with good tone, spontaneous breathing with no need for supplemental oxygen and resuscitation are enrolled in the study. BPL SMARTSIGN S12 monitor is used to measure SpO2. After delivery, the pulse oximeter probe was placed at the right wrist or palm (pre-ductal) of the neonates lying in the servo controlled radiant heater. The probe of the pulse oximeter was attached for at least 1 min until the highest stable level with a good waveform is registered. Data was recorded from 5 to 15 mins of life and also the time taken for oxygen saturation to reach >=90% was recorded and compared to the mode of delivery, gestational age, gender and birthweight. Conclusion: In healthy term newly born infants, oxygen saturation rises slowly and does not usually reach 90% in the first 5 minutes of life and moreover, it was similar to the other studies reported earlier. SpO2 monitoring may help in infants requiring resuscitation to avoid overexposure to high O2 concentrations after birth. There is statistically significant difference in terms of mode of delivery and gestational age. However, a clinically insignificant statistical significance was observed with gender and with birth weight.