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VOL. 9, ISSUE 4 (2023)
Thrombocytopenia in pregnant women with malaria parasite
Authors
Ngwu Amauche Martina, Ozoemena Chiadikobi Lawrence, Maduachi Cynthia Ogochukwu
Abstract
Thrombocytopenia is a condition that occurs when platelet count is
below 150,000 platelets per microlitre of circulating blood. The assumed
structure that cause thrombocytopenia during malaria infection are: the
involvement of platelet as cofactor in causing severe malaria, coagulation
disruptions, bone marrow changes, splenomegaly, oxidative stress and antibody
-mediated platelet destruction. The aim of the study was to determine the
platelet count and platelet indices of pregnant women infected with malaria
parasite. Sixty five pregnant women identified as positive for malaria by
microscopy (PfMbM), twenty five pregnant women identified as negative for
malaria by microscopy (NfMbM) and twenty six non-pregnant women were enrolled.
Platelet count (PC), mean platelet volume (MPV), platelet distribution width
(PDW), plateletcrit (PCT), platelet-large cell ratio (P-LCR), platelet large
cell coefficient (P-LCC) and total white blood cell count (TWBC) were measured
by automated haematology analyzer. The case control study was conducted between
June and September 2022. Among 65 pregnant women identified as PfMbM, 6 (9.2%)
had mild thrombocytopenia (100-<150 x 109/L), 4 (6.2%) had
moderate thrombocytopenia (50-<100 x109/L) and 3 (4.6%) had
severe thrombocytopenia (<50 x 109/L). P-LCC levels were 67.33 ±
19.05 x103/µl in pregnant women identified as PfMbM and 57.76 ±
15.74 x103/µl in control group p=.0.003. Platelet counts were 295.13
± 95.00 x 109/L in NfMbM group and 233.50 ± 106.64 x 109/l
in PfMbM group p=<0.001, whereas P-LCC were 67.33 ± 19.05 x103/µl
in PfMbM and 74.89 ±23.68 x103/µl in NfMbM group p=0.018. Also PC
were 279.24 ± 82.16 x 109/L in PfMbM with one plus and 234.71 ±
84.14 x 109/L PfMbM group with two pluses p=0.022. The comparison
between the first, second and third trimester showed significant decrease in PC
176.19 ± 77.51 x 109/L in third trimester compared to first
trimester 225.17 ± 51.51 x 109/l p=0.049. The study showed presence
of mild, moderate and severe thrombocytopenia, significant increase in platelet
large cell coefficient in pregnant women identified as positive for malaria by
microscopy The study recommends regular malaria test and platelet count in
pregnant women during antenatal period.
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Pages:7-10
How to cite this article:
Ngwu Amauche Martina, Ozoemena Chiadikobi Lawrence, Maduachi Cynthia Ogochukwu "Thrombocytopenia in pregnant women with malaria parasite". International Journal of Medical and Health Research, Vol 9, Issue 4, 2023, Pages 7-10
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