Small bowel tumors are rare, accounting for only 3-6% of gastrointestinal (GI) neoplasms, 12% of them being malignant. The most common histologic subtype is adenocarcinoma. Primary jejunal adenocarcinoma constitutes a very small portion of small intestinal adenocarcinoma. Clinical manifestations of this entity occur in advanced stages of its progression and it is often difficult to diagnose. It presents with nonspecific symptoms. Prognosis is not good usually. Surgical resection is the treatment of choice at early stage, however no standard protocol has been established for chemotherapy in unresectable or metastatic disease.

Case Report: We report a rare case of Primary jejunal adenocarcinoma in a 65 year old female presenting with long standing anemia and generalised weakness. Various investigations like Upper Gastrointestinal (GI) Endoscopy, Colonoscopy, Contrast enhanced computed tomography (CECT) of whole abdomen were done, but the exact location of the tumor could not be determined preoperatively. Exploratory laparotomy was performed, which revealed a cystic mass in the proximal jejunum. Segmental resection of the part of jejunum containing the cystic mass was done along with regional lymph node resection. Histopathological examination of the resected specimen was done and a diagnosis of Adenocarcinoma was made.

Conclusion: Primary small bowel adenocarcinoma, more precisely Primary jejunal adenocarcinoma is a rare entity and frequently presents with non specific clinical symptoms.