Background and Objectives: Type 2 Diabetes Mellitus has emerged as a difficult health issue due to its rising incidence and rate of complications. Research on Diabetes Mellitus (DM) has mostly focused on understanding the role of oxidative stress and inflammation as underlying mechanisms for pathogenesis and preventing long-term consequences. The study aims to study the association of serum gamma-glutamyl transferase (GGT) and high sensitivity C-Reactive Protein (hs-CRP) levels with glycemic control (HbA1c) in type 2 Diabetes Mellitus patients with controlled Diabetes Mellitus type 2, uncontrolled Diabetes Mellitus type 2 and nondiabetic groups. The correlation between GGT and hs-CRP with glycemic control (HbA1c) was also studied in this research.

Material & Methods: A Hospital based observational study was conducted on 108 subjects which consisted of three groups of whom 36 subjects were type 2 DM patients with HbA1c level less than 7% (Group 1) ,36 subjects were type 2 DM patients with HbA1c level more than 7% (Group 2) and group 3 consisted of age and sex matched healthy subjects. Serum GGT, serum hs-CRP, Fasting Blood Sugar (FBS) and glycated hemoglobin (HbA1c) levels were measured in this study.

Results: The levels of mean serum GGT and serum hs-CRP were significantly raised in type 2 DM patients with poor glycemic control when compared to patients with good glycemic control and normal healthy subjects; p-value <0.001. There is a significant positive correlation between GGT and hs-CRP with HbA1c and also between GGT and hs-CRP.