Takayasu's arteritis (TA) is a granulomatous vasculitis of unknown etiology that primarily affects the aorta and its major branches, mainly in young women. Although neurological manifestations are uncommon during the initial phase, the occurrence of acute stroke as the initial presentation in patients with Takayasu's arteritis is rarely reported.

We report the case of a 26-year-old woman admitted for an inaugural ischemic stroke. Clinical examination and vascular investigations revealed signs suggestive of Takayasu's disease, allowing for an early diagnosis. The patient was started on systemic corticosteroid therapy combined with an antiplatelet agent, resulting in a favorable clinical outcome.