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VOL. 11, ISSUE 1 (2025)
The zebrafish genome: Unveiling human disease mechanisms and drug target
Authors
Asmita Mitra, Biswadeep Das
Abstract
The zebrafish (Danio rerio) has emerged
as a key model organism in biomedical research, considerably improving our
understanding of human disease mechanisms and medication discovery. This study
investigates the structural and functional similarities between the zebrafish
and human genomes, revealing that roughly 70% of human protein-coding genes are
zebrafish counterparts. These genetic connections enable zebrafish to
effectively model human disorders, providing important insights into gene
function, developmental biology, and disease etiology. Zebrafish offer distinct
advantages, such as rapid development, transparent embryos, and high-throughput
screening (HTS) capabilities, which allow for real-time observation of genetic,
molecular, and physiological processes. Researchers can use modern techniques
like CRISPR/Cas9 to generate precise genetic models of human disease states
ranging from neurological illnesses to malignancies. Zebrafish also play an
important part in drug discovery, providing for fast screening of drug
candidates as well as cost-effective assessments of toxicity and efficacy.
Zebrafish incorporation into personalized medicine enhances individualized
therapeutic research by allowing for the study of patient-specific genetic
alterations. This study emphasizes the importance of zebrafish in translational
research, where their genetic and physiological parallels to humans, combined
with their flexibility in high-throughput applications, make them an invaluable
tool for understanding disease pathways and speeding up medication development.
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Pages:38-44
How to cite this article:
Asmita Mitra, Biswadeep Das "The zebrafish genome: Unveiling human disease mechanisms and drug target". International Journal of Medical and Health Research, Vol 11, Issue 1, 2025, Pages 38-44
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