Aims & Objective: The purpose of this study was to evaluate the relationship between serum trace elements with aminotransferases (SGOT, SGPT) tests among chronic liver disease (CLD) patients.

Introduction: Aminotransferases, specifically aspartate aminotransferase (AST, formerly SGOT) and alanine aminotransferase, serve as fundamental biomarkers for hepatocellular injury and LFT ^[1]. These enzymes are released into the bloodstream when liver cells are damaged or destroyed, making them essential diagnostic tools in clinical hepatology ^[2]. Simultaneously, trace elements including zinc, copper, selenium, iron, and manganese play crucial roles in liver metabolism, for maintaining hepatic homeostasis ^[3].

The liver serves as the primary organ for trace element metabolism ^[4]. Recent advances in molecular biology have elucidated complex interactions between trace element status and liver function ^[5]. Understanding these relationships help in maintaining strategies for liver diseases ^[6]. Essential trace elements participate in oxidative stress regulation, inflammatory responses, and fibrogenesis pathways ^[7]. Disruption of trace element homeostasis can lead to altered liver enzyme levels ^[8]. The correlation between aminotransferases and trace elements encompases interactions that influence liver health outcomes ^[9].

Material &Methods: A cross-sectional study was conducted among 300 chronic HBV patients at Jhalawar Medical College, Rajasthan, India. This comprehensive review synthesizes data from multiple observational studies, clinical trials, and population-based research examining the relationship between aminotransferases and trace elements ^[10]. The primary endpoints examined were correlations between serum AST/ALT levels and concentrations of zinc, copper, selenium, iron, and manganese ^[11].

Population studies included data from the National Health and Nutrition Examination Survey (NHANES), European cohorts, and Asian populations, providing diverse demographic representation ^[12]. Laboratory measurements employed atomic absorption spectrophotometry for trace elements and standardized enzymatic assays for aminotransferases ^[13]. Statistical analyses utilized correlation coefficients, multivariate regression models, and adjusted analyses controlling for demographic and clinical variables ^[14].

Results: Zinc, Selenium deficiency demonstrates a strong positive correlation with elevated aminotransferase levels. Elevated liver copper, iron content correlates positively with fibrosis severity and aminotransferase elevation. Mangnese also correlates positively with ALT &AST