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VOL. 12, ISSUE 2 (2026)
Myelodysplastic syndrome: An update narrative review of literature
Authors
Austine-Okezie Ogechukwu Lucy, Alphonsus Ogbonna Ogbuabor, Silas Anayo Ufelle, Dorathy Chizoba Onovo
Abstract
Myelodysplastic syndromes (MDS) are a group of
clonal malignant hematopoietic stem cell disorders characterized by dysplastic
morphology, cytopenia and a predisposition to acute myeloid leukemia. These
dysplastic changes are a result of chromosomal abnormalities and somatic
mutations. MDS is the most common myeloid neoplasm of the older adults with
median age at diagnosis being 72 years and an average incidence rate of 4.9 per
100,000 people per year. MDS is diagnosed and classified according to the WHO
classification system, which utilizes peripheral blood and bone marrow
findings. Other essential investigations include flow cytometry, genetic
profile and chromosomal analysis. Various prognostic scoring system have been
developed which help guide the treatment. Treatment of complications associated
with MDS also forms an essential component of the management of this disease.
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Pages:24-27
How to cite this article:
Austine-Okezie Ogechukwu Lucy, Alphonsus Ogbonna Ogbuabor, Silas Anayo Ufelle, Dorathy Chizoba Onovo "Myelodysplastic syndrome: An update narrative review of literature". International Journal of Medical and Health Research, Vol 12, Issue 2, 2026, Pages 24-27
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