Type 2 Diabetes Mellitus (T2DM) entails a multifaceted global health crisis involving metabolic and immunological system disruptions. This cross-sectional study examines the relationship between blood pressure, Self-Monitoring of Blood Glucose, dietary compliance, and the effect of these variables on the immunological and hematological parameters of 124 participants aged 30-85 (97 T2DM patients and 27 healthy controls) of both genders from Sinjar General Hospital. The study utilized a laboratory and questionnaire-based approach to assess blood glucose levels, inflammatory markers (IL-1, IL-17A, IL-37) using the ELISA technique, and blood parameters using a CBC analyzer. Our study showed that patients with abnormal blood pressure had a higher value of exhausted immune cells, represented by a lower value of anti-inflammatory cytokines. In addition, the participants who practiced Self-Monitoring of Blood Glucose and maintained a healthy diet showed better blood glucose levels. On the other hand, IL-1 and IL-17A levels reflected the sustained pro-inflammatory activation and showed the existence of a glycemic control and disease duration deficiency. On the other hand, IL-37 had a lower level in patients with renal failure. In patients with uncontrolled hyperglycemia, the hematological changes were more prominent, supporting the interactions between metabolic, inflammatory, and immune changes in T2DM. This study encourages the reduction of multiplism to simplify a T2DM patient's care and optimize the clinical outcome of T2DM by focusing on the control of cardiovascular risks, Self-Monitoring of Blood Glucose, and dietary compliance.