Over the years, Orthodox medications are accessible for the treatment of chronic and acute medical conditions, a large portion of which are accessible over the counter (OTC) and are affordable. Some medications are named prescribed medications on the grounds that their use requires strict supervision by medical personnel. Both over the counter and doctor-prescribed medications are effectively abused among people in the general public. Rohypnol is a prescription drug that is otherwise called the "Date Rape Drug"; and is regularly utilized by Rapists to quell their victims as the medication has a high power and capacity to cause strong amnesia in victims. This study was designed to elucidate the effects that exposure to Rohypnol can cause in the cerebellar tissues of Wistar rats. The histological differences between the selected organ of control and treatment groups were evaluated. The results obtained showed notable changes within the layers of the cerebellum. The granular layer and white mater showed severe disruptions and vacuolations and vascular congestions. There was also reduction in number of purkinje cells within the purkinje layers. The results obtained from this current study indicate that Rohypnol was injurious to the cerebellum, and thus could lead to possible impairment of cognitive functions. It is therefore recommended that its arbitrary use should be discouraged and should only be used for therapeutic purposes under a Physician.