Backgrounds: Non-specific low back pain (NSLBP) is a prevalent condition affecting individuals across all age groups and constitutes a major contributor to the global disease burden. Patients with low back pain (LBP) frequently present with proprioceptive deficits that may extend beyond the lumbar spine. Due to the anatomical and biomechanical connections between the lumbar spine and the knee joint, it is conceivable that LBP may negatively affect knee joint proprioception. Moreover, there is a significant deficiency in the literature concerning gender differences in knee proprioceptive function among young adults with NSLBP.

Purpose: This study aimed to investigate the influence of NSLBP on knee proprioception among young adults and impact of gender differences on knee proprioception in individuals with NSLBP.

Methods: Eighty-Eight participants diagnosed with NSLBP. their age range 18-26 years old with body mass index less than 30 kilogram/meter2 of both genders, allocated into 2 equal groups divided into A (males) and B (females). Both groups were assessed for the Oswestry Disability Index (ODI), deviation from a static absolute target angle, and knee joint proprioception measured using a digital inclinometer. SPSS was used to perform statistical analyses with a significance level of p< 0.05. Results: Results revealed no significant differences in mean knee proprioception between group A (mean = 30.97, SD = 3.62) and group B (mean = 30.28, SD = 5.42), p > 0.05. Proprioceptive accuracy and disability index scores showed no significant gender-based differences.